Maybe the Powerwerx work around will help...  Here is what they told me. 
  I will send you the attachment in a separate post.  //  K8JHR  //
_______________________________________
> James,
>
> Yes our USB cables have Prolific chips inside. Since Windows pushed out a 
> updated driver 3 weeks ago we've had a increase of service emails and calls 
> regarding cables failing.
>
> The attached service sheet will step you through the procedure to make sure 
> the correct driver is installed. This has fixed the majority of programming 
> problems we have encountered.
>
> Our serial programming cables do not use a chip. They communicate straight 
> through the comm port to the radio.
>
> Feel free to pass this information along. We are in the process of adding 
> this additional information to our troubleshooting section on our website.
>
> Brad Thomas
> Customer Service
> Powerwerx
>
> ===========================================
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